The production ramp-up of new aircraft is characterized by high complexity and planning and control chal-lenges caused by complex product design, supply chain and production processes. In the past, this resulted in significant delays and increased costs of the production ramp-up. Novel business strategies and planning and scheduling technologies promise better production control and risk mitigation during the ramp-up phase. The European research project ARUM has developed those business strategies and a new distributed decision support solution based on knowledge processing technologies. A simulation testbed was used to identify the most beneficial business strategies and to evaluate linked control strategies for the industrial use case of the Airbus A350 production ramp-up. This paper discusses the potential of simulations for the business strategy definition and for the validation of linked control strategies from the industrial end-user perspective.