We discuss the application of simulation to estimate a nominal, or target, processing times for work stations on a serial assembly line. The expectation is that having different processing times per station per product will increase the throughput of the line, compared to having a constant time for all stations. A demonstration case at ABB Robotics in Sweden will be presented. This is a small part in the “Process Automation for Discrete Manufacturing Excellence” project (PADME) involving five manufacturing industry partners and four research organizations, that aim at adapting Industrie 4.0 strategies and existing state-of-the-art technologies into new configurations, serving as a framework that can be used by similar industries.